Hi, this is Steve Adams and welcome to the Future of Personalized Medicine Summit. A one of a kind three day virtual event designed for high achieving professional CEOs, entrepreneurs, lawyers and doctors who are ready to take of their health and performance through cutting edge personalized and proactive healthcare solutions. In our conversations we dive into the expertise and uncover practical science based strategies that busy professionals can use to optimize their energy, mental clarity and longevity. We're going to explore real world applications, the latest innovations and actionable steps to help everyone in our audience prioritize their well being without sacrificing their personal success. So I want to welcome you this morning to Amy Spahic and Dr. Sam Fillingganain and they have an innovative technology that we're going to go over today. And I guess first thing as I just want to welcome both of you really quick and then I'm going to read your bio. How does that go? Welcome. Welcome Amy and Dr. Sam.

Thank you Steve.

Amy Spahic is the founder and chief clinical officer and Managing director of Cardiov Vision Care. Before joining this company, Amy spent eight years in the cardiac nursing field in six years as a cardiac clinical research coordinator for multiple clinics in Illinois, Indiana and Florida. Dr. Sam Fillingane is a DO and is the company's Chief Medical officer and co founder of the company. Dr. Fillingane has spent over 20 years specializing in reversing heart disease for extremely high risk patients. It's long been a goal of Dr. Philling Gain to see cardiovascular risk decline nationally as cardiovascular disease continues to be the leading cause of death and declining quality of life for so many good people all over the world.

Welcome guys. I'm really thankful to have you at the summit. Thank you. I'm glad to be here Steve. You bet.

So talk to me real quick. How did you guys come together? Give us a little bit of the backstory there. Well, 28 years ago I started doing cardiovascular risk reduction working amazingly enough. We started seeing platat going in reversal and that caught me by surprise because I was taking a new pathway based on some research and I then began teaching all over the nation cardiovascular risk reduction principles.

I got to meet the physician who developed a product called a multifunctional cardiogram and Amy had met with the same person and he put the two of us together at some point and we have since been like peanut butter and jelly in this business of and I want to come back to your comment there. Dr. Fillingane. Amy, do you want to also kind of share how your backstory here yeah, with Dr. Sam?

So we've been together for, I think it's almost. Almost 10 years. And Dr. Sam has been a big help with reversing a lot of the cardiovascular disease for many, many clients. He's someone that, you know, really needs to get in there and reverse this disease.

So a little background on me. As you know, I'm a cardiac research nurse, and what got me into doing the mcg and the heart scan is a long time ago, my father, you know, passed away from heart disease. This machine could have saved his life. You know, found out what was going on with him. And not only that, but it's saving mine.

You know, I have small vessel disease, which, you know, still, you know, physicians frown upon. But this is the only device that actually can catch this disease. And now I'm in reversal mitochondrial dysfunction. It has gone. And thanks to Dr. Sam, Fillingane help back in reversal. And when we say reversal, we're talking about the plaque actually being removed over time, right? Dr. Fillingane. Correct.

You could have 95% blocked arteries, and one day you have 0% blocked arteries. Yeah. And that's the thing I want to really draw out in this interview is that that is possible. We talk about that at tiger medical with our two doctors who follow protocols that help people reduce that type of plaque. And people don't want to believe it and talk about Dr. Fillingane. You know, you were the pioneer in this, I think you said when we met earlier, 26, 28 years ago. What are the fundamental drivers that have to happen for someone to experience blackout reversal? Well, the condition is caused by inflammation. So what has to take place is inflammation has to be removed.

And of course, if inflammation is getting into your blood vessels to create the atmosphere properly for plaque and you remove it, then you are going to be very successful because your body actually has a mechanism that will reverse it if you set the stage proper. The problem is that you got to know where the inflammation comes from, and one by one, turn the tap off. There's 11 disease states that create cardiovascular inflammation. And basically, with each patient, we find out which of the 11 disease states they have. And it's not good enough to just know what disease stage you have, but you have to know how to reverse that inflammation.

Where does the inflammation come from in disease? Once you can do both, hypervversal is quite possible. And so I find it very important that we get this information out. And this device is helping us see things so much quicker than we saw it before. And Obviously, it's a whole lot easier to fix a problem with with small amount of blockage than it is to Fix1 with 95% blockage.

And I think one of the things that a lot of patients don't realize, it's not a 95% blocked artery that causes most of the heart attacks. It's a 30 to 50% blocked artery that're ruptures. And those patients have no symptoms whatsoever before they have the heart attacks. So for 66% of patients who have heart attacks, they'll have absolutely no warning. And this device, one of their only tools of help.

Why would you see for a problem you didn't know exist because you had no symptoms. But this device here is something that you would use in the confines of a clinic, and it would be done yearly on a person because it's not expensive and it's not invasive, and it's very safe. And there's no reason not to do this test yearly. And it gives you a score, a cardiovascular score. So once a year you go get your regular physical exam and you get a number between 0 and 22.

But anything over 4 is considered significant. So if I had a score of 1.2 the first year, and a year later I went and had a 2.2, and then the next year I had a 3.2. Obviously my cardiovascular disease is getting worse. Whatever I'm doing, it's not working. And I've got to bear down and do better.

And what I don't want to do is let myself get over four. But this machine goes past that. I don't want to take up all the time here. Amy can talk too, but it see so many different things. One I'm most excited about is small vessel disease and mitochondrial dysfunction, because those are two things that are going to play a huge impact.

But now 5 million people in America have heart failure, and this actually sees heart failure six to eight years before it occurs. So if you had six, eight years warning, you might not ever get heart failure. And so if I was a heart failure patient today, I'd be disappointed knowing that I could have known this years ago. But let's try to catch the ones that hadn't got there already. And it's quite common for people that have insulin resistance and other inflammatory disorders to not only have plaque in their arteries, but they simultaneously the same inflammation is what's differ to the heart.

Yeah, Amy, you want to jump in on a little bit? Yeah, he did a great job. You know, I know it's 45% of women do have small vessel disease and you know, about 15% of men. So it's not just in women, it's in both. And, you know, we can catch it early and reverse it and hopefully help a lot of people and save lives.

Yeah. And it's also an African American community has a higher percentage of male and female with small vessel disease. Is my understanding is that corre. Well, this is pretty true across the board, to be honest. But yes, seem to have the fair, fair share of all large and small vessel disease.

But that being said, some people don't know how small vessel disease works because it works entirely different than large vessel disease. You get small vessel disease off of the little arteries that come off the bigger. There's four big arteries around the heart and there's little ones that come off that go straight into the muscle. Yep. When you start clogging up all those arteries over time, the clogging gets so severe you develop this incredible fatigue.

Fatigue is so severe you can't function, you can't work, you can't carry on almost any aspect of life. And so you end up medical help. Ultimately, you get a heart cath and the doctor sees nothing because large vessel diseases is all you can see on a heart gas. So the doctors of the opinion you're doing okay when you're really not. And then months later, the same patient will go from no large vesselse to 100% occlusion of the large vessels, so they convert quickly.

So usually six months of the heart cath, the patient has a heart attack and it's 100% occlusion of either one, two or three vessels. And so one of the reasons female heart disease has not been something that we can catch is because you got to catch it in that window. If you don't have a machine that can see the small vessel leave, but now this does. This device is an electrocardiogram that uses artificial intelligence and it sees small vessels disease very early and then it seizes as it worsens and it gives us a score. So when you're treating the small vessease that we can tell if the treatment is working.

If the treatment is working, the score goes down. And eventually, if I correctly fixedure small vessel disease, those numbers go down to zero. And that's a good feeling to go in the bed at night having zeros now. Yeah, I have pretty much all zeros on my scores, and that's because I've been doing this a long time and taking care of cardiovasc disease. If you know how this Works, you get tested and you address it.

Occasionally. I've had a little score. When I had Covid a while back, I had a few points. I addressed the issues, tagged in with the COVID and went back to zeros. And so, you know, that's something I want to follow up on.

Have you seen a negative impact from the COVID And I'm not for or against vaccines on this summit, but have you seen negative effects on people's cardiovascular health from repeated use of the COVID vaccine? Yes, but now we've also seen it from the infection. And, you know, we went through a terrible pandemic, and with anybody's guess what was. So you don't see much of it anymore. The people that had vaccine injuries, most of them have been treated.

Hopefully they gotten the people that understand how it works and their scores go back down to zero or wherever they were. Yeah. Because I had four shots. And, you know, in full disclosure for everybody, I did this test with Amy and Dr. Philinganeain, and it was tremendously informative.

You guys mind if I share my story a little bit? Sure. Because it really makes the point. So I come from a family where a lot of cancer and a lot of heart attacks. And so that was part of my journey of why I started Tiger Medical.

I wanted to have a proactive medicine company to address lifestyle and root cause medicine. And so I did everything I thought I could do. I did advanced lipid marker panel, and for the most part, that's really good for me. We did a calcium score and I had a zero. And then I did a clearly scan, and the person said I had zero blockage in my large arteries.

And then I'm involved in another company that actually measures your microvascular health. And I had a low score there. And Dr. Vinck on our team said, it's the canary in coal mine. Steve, you got something, you need to go dig in deeper and look for that.

So I came and I got tested by Amy, and I, in fact, have, you know, small. What do you call it? Corner. Yeah, yeah, right.

And so it literally, for me, I was cruising along thinking, I'm just fine and I'm not. And there's so many stories like that, and I'm so thankful for what you guys have brought to the world. But there was something else that came out of that that I think I want to explore now next, and that is mitochondrial health. Can one of you first of all describe what is mitochondria? What's its function, and why is it important?

Mitochondria is an organelle within the cell. And its primary function is to produce energy that allows the cell to run. It's your battery powered within the cell. And when your cells have adequate energy, they function at maximum capacity, and they do well. But we've known for a long time that there's a large subset of patients, as they age and as they develop disease states, especially inflammatory disease states, their mitochondria become overwhelmed and they no longer have the adequate amount of energy to function at a normal pace.

And what happens then is these cells become concerned. Imagine being a cell within a body where all the cells in the body only have 70% of the energy they need. And you realize you were at 80% a month ago, and so you're declining. And you see yourself going down to 60 and 50, and you're worried about survival. Now, those cells, when they worry about survival, they start to mutate.

And as they mutate, they go from what usual ATP is made from oxidative phosphorization, and they're mutating to a form a cell called fermentation. And fermentation is cancer. And so there are literally millions of people in the United States run around with mitochondrial dysfunction that don't know it. Now, when your cells mutate, they rarely make it to the other side, become tumors. More time and not the cells do not survive.

And cells behind them come and try to do the same thing. But then your immune system recognizes them as abnormal, which triggers the mechanism for autoimmune. So here you have a problem within a cell that creates the inflammatory issues that relate to cardiovascular disease. It creates the cell mutation that triggers autoimmune illness, and it prompts the cell to change the way it makes energy to eventually become a tumor. And cancer comes from that.

So it's a serious problem. And until I had access to a multifunctional cartogram, we abbreviated mcg. I had never known how many people had mitochondrial dysfunction. There is no procedure that you can do in an office that tells a person they have mitochondria dysfunction. There are a few blood tests you can do that would give you the presumption you might have mitochondria dysfunction.

But this test not only tells you have it, it gives you a score. And you're treating the mitochondrial dysfunction. The score goes down if the treatment is working. Obviously the score gets worse if are not working. And so you definitely do not want to allow a person to stay with myonder dysfunction.

I've seen patients through the years that had one tumor right after another, they would get one, they would get over it and they would get a second tumor. Then they'd get over._in and these are patients with mitochondrial dysfunction. And had we known that historically, I think we would have done things to reduce the inflammation. And then as you reduce the inflammation, you take the burden away from the immune system and then the cell is able to make enough energy to do the work. It's the system burden that creates the problem for ATP.

And so inflammation has always been that thing and it tags in with the immune system. And so this is the first test that we have, this office base that can pick up mitochondrial dysfunction historically called the way we pick it up as in a research lab. And so someone is going to look and see if they got cardio problems and they also can learn if they have mitochondrial problems which relate to cancer as well. Autoimmune and autoimmune. Yeah.

And I'm wondering now we see a fair amount of autoimmune in our 50 plus patients in our company and would you say that mitochondrial dysfunction is the core root cause of autoimmune? Do it is a core. It is a cor. Okay, got it. I It's The only pathway, but it is a pathway offence when I so I have this concern myself.

This is what came out of the testing. So I did a bunch of research and found that know one of the ways to support mitochondrial health is a host of about six, seven, eight habits. But it's beyond that. How do you.

I don't want to answer the question. I know what the answer is, but I want you guys to answer it. There's some help in people's genetics. Like you can get a genetic test and that can lead you down this path where you go looking for mitochondrial_ysfunction do you guys want to unpack that a little bit for me? Well, one of the 11 disease states that triggers inflammation is genetic in nature.

So the biggest one is the MTHFR genetic mutation, which is in 50 to 60% of the American population. So over one out of two people have this disorder and as they get 25 years of age, it becomes a problem. And by the time they're 50, it's a big problem because there's four chemicals in their brain they can't make and that creates problems with brain function, which leads to inflammation because of the way the brain compensates. And it also prevents them from making nitric oxide. And it's basically a mutation that stops you breaking folic acid.

Down to the fifth product called methylfolate. It doesn't do anything in the body. It's the methylfolate that does it. And so many people have this and don't know it. And it's not commonly known in all medical circles.

I read an article of the day that said 49% of psychiatrists know about it, but less than 5% of primary care physicians are aware. Nthr genetic mutation. So it still hasn't circled the medical arena yet. But long story short is very big and it causes a lot of cardiovascular and it triggers mitochondrial dysfunction. It's one of the 11.

Yep. Well, it'so. It's. I think the lesson here if you're listening in, is it's important to get tested for your genetics and find out if you have this. And if you do, you're going to have mitochondrial dysfunction as you age.

Do people that don't have the variants, do they experience mitochondrial dysfunction just from lifestyle? Just diabetes alone or prediabetes can trigger it. Can have problems with dyslipidemia, possibly you drink too much alcohol or eat too much high fructose corn syrup, maybe you have hypertension that's triggering it. As sleep disorders, which are quite common today in chronic kidney disease, can trigger it. Mental health issues will trigger it.

Allo Immune issues and chronic inflammation. Some people run around with chronic Lyme disease or they have some heavy metal toxicity or they have mold exposure in their house. Any of those things can trigger it. Leaky gut syndrome, which is very common with the aging and it's even common in young people that have had a lot of antibiotic exposure. Right.

So yeah, our doctors say it's about 90% come to us with leaky gut do. It's very common and I think for years it's hard to go through life without some infection that leads you toward an antimicrobial. And then I think in younger years when I went through training, we were not talkaughed to after you give something of that nature to treat this person's biogenome with caring probiotics and freebiotics to rebuild what you damaged. And so I think you leadave the damage. And then as you age, even if you haven't been on a lot of antibiotics, your biogeome degenerates.

And so you've got maybe a third less cells than you had to start with. Most people don't. Their Biogenome is a 10 to 1 ratio to their cells. So if you have 10, 10 trillion cells in your body, you have a hundred trillion cells in your biogeome. So it's a very active network of germs that start into your jujunum and work their way through your colon.

There's only three layers of your gut. There's a mucosal layer, there's a titight chain layer, and then there's an inflammatory or an immune layer. And that immune layer is where 70% of your immune cells lay in. There would be no reason to put 70% of your immune cells in your gut if your gut didn't leak quite regularly. Yeah, right.

So go ahead. I'm sorry, doctor. Cause your tight chains to let go, or when you eat too many sweets, or you eat more carbs than your body will tolerate, or when you drink alcohol with excess, or when you have too much high fructose corn syrup. So there's a lot of reasons to cause the tight chains to let go. That muus is actually eaten by the germs within your biologenome that when they don't get fed the proper amount of fiber, they will start eating your mucin layer.

You can food with emulsifiers in it and you that will basically remove the mucin layer. And then if you remove the mucin layer, eat the wrong amount of sweets or fructose or alcohol, and then there's nothing left but your immune system layer. So leaky gut is actually quite common. And if these get into your bloodstream, they will cause problems. And finding that bacteria are actually in the brain in various cases and they don't belong crossing into that market, but they do.

Because basically you've got a sewer transferring through your intestinal tract, I.e. ling holes in your intestinal system. Imagine how much of an stress that puts on your immune system when you've got 50 leaks in your intestine here and there, right? So somebody finds out they have small vessel disease at some level, they find out they've got mitochondrial dysfunction. You give them a plan that will target it.

And what kind of time, first of all, can they reverse it? Number one, and I think we know part of the answer because we talked about cardiovascular already. And secondly, what kind of time is involved to reverse it typically depends on the shape you're in. You've been shot by a cannon, it makes a bigger hole than if you got shot by a BB gun. But assum, it's a bad one.

It may take weeks or months, but you know, the first job is to repair the leaks and then you've got to restore the germs to adequate health. More times than not, when you've done that, you've stirred up your mast cells in your gut. So you might have some reflux, some constipation, some diarrhea or all the above. And so after you go through the leaky gut regimen, you have to take care of a mast cell activation synd activity too. And when you put it all in concert, you start eating foods that you had stopped tolerating and you start tolerating them again.

And so some of the things that you thought you were intolerant you actually could do okay with. But you have to feed these norms. And we used to put probiotics down without prebiotics. And so. Right.

You were putting germs down in a hostile environment, but not feeding them well enough that they couldn't sustain life. So it was kind of like pouring something into the abyss and nothing but. Yeah, we learned about the prebiotics and even some postbotic regimens. It created some stability for these germ matrices. And you know, the biogenomes that you see in Florida versus what you see in New York versus what you see in California or Mississippi, they're all different.

And so it is a complicated set of details. And so how I treat you in your state versus the other, it could vary because of what is actually going on in the two different areas. Sure. Then you get a weird guy like me who's been in 45 countries in the last 20 years and I probably have some unique stuff. Proably so.

Yeah. Well I've on my third mucosa and biome regimen with just cause we keep after it. But, but I know that's great. So, but somebody if they make a real commitment and they follow what you're saying in a year they can really transform their health. When you say is a fair statement. Typically night, day difference. People with leaky gut, for instance, they have a slowing of their brain. They tend to not think as clearly as they used to reduced.

And they think that maybe it's just old age. And it's not. It's leaky gut that is basically playing habit with their nerves. Now you know, the fear factor is, is as you play havoc with your nerves in your brain too much with this, you can cause some nerve retraction. And that is the beginning of how you develop Alzheimer's or, or dementia with aging.

But you can correct that just by fixing the leaky gut. And then memory comes back and energy gets better and life goes back. So all these people that think they're getting older just because that's just what happens. They need to rethink that strong and you'll be amazed at how well they can doe including what lifestyle optimization. Ye Amy, go ahead.

You want to keep going? Yeah, a little lifestyle changes. You know, we're so used to a habit and it's bad habits that we have. So if we can reprogram our brain onto eating healthy and trying, you know, the less the carbs is better for patients who do have a MTHFR condition and you know, insulin resistance, we have to watch our carbs. And Dr.Sam has a great program on low carb, less than 25 grams carbs every four hours. And if we just retrain ourselves to be healthy, we can reverse this disease faster. Right. Well, and you know, so I guess I would encourage people get tested genetically so you know what you're dealing with. And then, you know, especially people as they're starting to reach middle age.

It really is important that you take a look at your health from a different perspective than the standard annual physical. I'm not disparaging anybody in traditional medicine, but there's limitations to that method and especially in terms of preventative and seek out a functional medicine type physician who's going to look at things from a root cause. That's everything we do at Tiger. We've done that for five years. And then if you work with us, you're going to visit with Amy and Dr.Sam because that's just standard protocol now for all patients that go through Tiger. But also how can Amy, how can they find you guys directly? Like if they've already done some of that stuff and they just want to find out, they want to have that consult with Dr. Sam like I had. That was so terrific.

How do they find you guys? Yeah, they can go on the website CardioVisionCare.com DoA there's a little link at the bottom of the page where they can click on info@CardioVisionCare.com and just send a quick message that they want to schedule an appointment or just want to talk or consult. And we're pretty quick to respond so they can reach out through that. And when they typically come to Jacksonville or there more places around the country. How does that work?

We're nationwide and international so depending on you where they're located, we'll find out and we'll set up an appointment where we can come to their home. The machine is mobile so we can come to the place of business, their home. They can come to the office in Jacksonville which is 3410 Corey Road and that's Jacksonville, Florida, 32577 I'm Sorry 32257. And they can come over here and get scanned or, you know, just meet with me and talk and look at the machine. If they want to incorporate into their corporate wellness programs or, you know, we come and do scan days at clinics.

So we have locations in Longwood, Florida, Lakewood, Florida, Clearwater, now Miami. And then we're hoping to get Tennessee and a lot more to come. Dr. Sam, any last words you want to share? Find a way to get this test done because this test is a game changer. For those of you that think there's nothing wrong with me, remember that two out of three, two thirds of people that do have heart disease have no knowledge of it until the heart attack itself. I hope everybody stays healthy and there's a high percentage of people who die in their first heart attack.

Is that true? That's correct. Yeah. So anyway, I'm grateful. It's having a major difference in my life and I can't recommend it enough.

And thank you guys for joining the summit. We're so grateful.